Italian Ministry of University of Scientific Research
New designed triazoloquinolones in combination with Pgp inhibitors as useful chemical probe to investigate quinolone resistance in Mycobacterium Tuberculosis: an approach to face an old re-emerging disease with new tools
Time: 3 years; Budget: 3 K€
- A multidisciplinary project combining computer-assisted design, synthesis, chemico-physical characterization, biochemistry, molecular biology and in vitro assays for the development of new, more efficient antitubercular drugs.
Pricl et al., Design, synthesis and antitubercular activity of 4-alkoxy-triazoloquinolones able to inhibit the M. tuberculosis DNA gyrase. European Journal of Medicinal Chemistry 2019;161:399-415.