Italian Ministry of University of Scientific Research

New designed triazoloquinolones in combination with Pgp inhibitors as useful chemical probe to investigate quinolone resistance in Mycobacterium Tuberculosis: an approach to face an old re-emerging disease with new tools

Time: 3 years; Budget: 3 K€


  • A multidisciplinary project combining computer-assisted design, synthesis, chemico-physical characterization, biochemistry, molecular biology and in vitro assays for the development of new, more efficient antitubercular drugs.

Pricl et al.,

Pricl et al., 2Pricl et al., Design, synthesis and antitubercular activity of 4-alkoxy-triazoloquinolones able to inhibit the M. tuberculosis DNA gyrase. European Journal of Medicinal Chemistry 2019;161:399-415.